IMMUNOPROTECTION OF SOLUBLE EGG ANTIGENS AND PRAZIQUANTEL IN CHALLENGED MURINE SCHISTOSOMIASIS MANSONI
نویسندگان
چکیده
منابع مشابه
Immunoprotection of Mice against Schistosomiasis Mansoni Using Solubilized Membrane Antigens
BACKGROUND Schistosomiasis continues to be one of the most prevalent parasitic diseases in the world. Despite the existence of a highly effective antischistosome drug, the disease is spreading into new areas, and national control programs do not arrive to complete their tasks particularly in low endemic areas. The availability of a vaccine could represent an additional component to chemotherapy...
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A Schistosoma mansoni cercarial antigen preparation (cercarial transformation fluid--SmCTF) was evaluated for detection of anti-schistosome antibodies in human sera in 4 collaborating laboratories. The performance of SmCTF was compared with that of S. mansoni egg antigens (SmSEA) in an indirect enzyme-immunoassay (ELISA) antigen assay, the latter being used routinely in 3 of the 4 participating...
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The antischistosomal activity of clonazepam, when administered alone or in association with oxamniquine and praziquantel, was experimentally evaluated in mice infected with Schistosoma mansoni. The animals were treated 45 days post-infection with a single dose, by oral route, according to three treatment schedules: clonazepam 25 mg/kg and sacrificed 15 min, 1h or 4 h after treatment; clonazepam...
متن کاملNaïve donor responses to Schistosoma mansoni soluble egg antigens.
Schistosome infection induces profound Th-biasing and immune suppression. Although much has been examined in mice, few studies have examined responses of naïve humans to schistosome antigens. In this study, we examined the response of naïve human peripheral blood mononuclear cells (nPBMC) to stimulation with Schistosoma mansoni soluble egg antigen (SEA) using a priming in vitro (PIV) assay. We ...
متن کاملOxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni.
The activity of lovastatin associated with oxamniquine or praziquantel against schistosomiasis mansoni was evaluated in mice infected with Schistosoma mansoni. Forty days after infection, mice were treated with lovastatin, 400 mg/kg for five consecutive days by oral route, and on the last day of this sequence with 50 mg/kg oxamniquine or with 200 mg/kg praziquantel, both by oral route, single d...
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ژورنال
عنوان ژورنال: Journal of the Egyptian Society of Parasitology
سال: 2017
ISSN: 2090-2549
DOI: 10.21608/jesp.2017.77954